E2B(R3) Ready, FDA Mandate April 2025

Adverse event reporting,
simplified.

Replace paper forms and email chains with an enterprise-grade electronic intake system. Capture, triage, and generate E2B(R3) reports, in a fraction of the time.

Adverse Event Intake Live
Product Name
Pembrolizumab 200mg IV
Event Description
Grade 2 hepatotoxicity, elevated ALT...
Seriousness Assessment
Serious, Medically Significant
E2B(R3) ✓ AI Triage

Manual adverse event processing is breaking PV teams

01

Paper & Email Intake

Reporters submit AEs via PDF, fax, or email. Data is re-keyed manually, introducing errors and delays into every single case.

02

40+ Hours Per Case

Each serious case takes days of manual triage, coding, narrative writing, and regulatory formatting before it can be submitted.

03

E2B(R3) Deadline Looming

The FDA mandate is here. Legacy systems can't generate compliant XML. Small biotechs face $500K+ enterprise safety database costs.

Electronic Intake

Enterprise-grade intake form. Zero paper.

Give reporters a secure, guided electronic form that captures structured data from the start, no more deciphering handwritten forms or parsing email attachments.

  • 5-step guided workflow with real-time validation
  • Secure link shared with reporters, no login needed
  • PII encrypted at rest with AES-256
  • Auto-generates unique case IDs instantly
Step 1, Reporter Information
Dr. Sarah Chen, MD • Oncology
Step 2, Patient Details
J.M. • 67 • Male
Step 3, Product Information
Pembrolizumab 200mg IV q3w
Step 4, Event Description
Grade 2 hepatotoxicity, onset Day 21...
Step 5, Review & Submit
✓ Complete, Ready to submit
Customizable

Your form. Your brand. Your rules.

Configure intake fields, add product lists, set required fields, and apply your organization's branding, all from an admin panel. No development needed.

  • Drag-and-drop form builder
  • Custom branding, logos, and colors
  • Per-product field configuration
  • Multi-organization support
Patient Age Field
Concomitant Medications
Medical History
Lab Results Upload
Reporter Signature
E2B(R3) Compliant

One-click regulatory report generation

Generate ICH E2B(R3) compliant XML from structured case data instantly. No manual mapping. No format errors. Ready for FDA, EMA, and global submissions.

  • Automatic E2B(R3) XML generation
  • FDA & EMA gateway-ready format
  • MedDRA coded events
  • Built-in validation before submission
<ichicsr lang="en">
  <safetyreport>
    <reporttype>1</reporttype>
    <serious>1</serious>
    <seriousnesshospitalization>
      1
    </seriousnesshospitalization>
    <primarysource>
      <qualification>1</qualification>
    </primarysource>
  </safetyreport>
</ichicsr>
AI-Powered Triage

40 hours to 2. That's not a typo.

AI handles the heavy lifting, seriousness assessment, MedDRA coding, causality analysis, and priority assignment, so your team focuses on decisions, not data entry.

  • Automated seriousness classification
  • AI-suggested MedDRA preferred terms
  • Causality assessment with reasoning
  • Priority-based case queue
Average case processing time
40h
Manual Process
2h
With AE Connect
That's 95% less time per case, hours back every week for your PV team.
95%
Reduction in Processing Time
0
Paper Forms Required
100%
E2B(R3) Compliant
<5min
To Deploy an Intake Form
Enterprise Security

Built for regulated environments

AE Connect is architected from the ground up for pharmaceutical compliance, with encryption, audit trails, and access controls at every layer.

🔐
AES-256 Encryption
Data at rest & in transit
📋
Full Audit Trail
Every action logged
🛡️
Role-Based Access
5-tier permission model
☁️
AWS Hosted
HIPAA-eligible infra
🏥
ICH E2B(R3)
FDA & EMA compliant

Ready to modernize your
adverse event reporting?

Start with a free pilot. No credit card. No commitment. See how AE Connect transforms your PV workflow in days, not months.

Start Free Pilot Schedule a Demo